| 2021-08-07 15:00:13August 7, 2021 | Exeter City vs Bradford City | 0 - 0 | League 2 | St James Park, Exeter |
| 2021-08-10 19:45:17August 10, 2021 | Exeter City vs Wycombe Wanderers | 0 - 0 | Carabao Cup | St James Park, Exeter |
| 2021-08-14 15:00:16August 14, 2021 | Leyton Orient vs Exeter City | 3 - 0 | League 2 | Brisbane Road |
| 2021-08-17 19:45:50August 17, 2021 | Barrow AFC vs Exeter City | 0 - 0 | League 2 | Holker Street |
| 2021-08-21 15:00:36August 21, 2021 | Exeter City vs Bristol Rovers | 4 - 1 | League 2 | St James Park, Exeter |
| 2021-08-24 19:00:02August 24, 2021 | Exeter City vs Chelsea B | 1 - 1 | EFL Trophy | St James Park, Exeter |
| 2021-08-28 15:00:30August 28, 2021 | Harrogate Town vs Exeter City | 1 - 1 | League 2 | Wetherby Road |
| 2021-09-04 15:00:57September 4, 2021 | Exeter City vs Forest Green Rovers | 0 - 0 | League 2 | St James Park, Exeter |
| 2021-09-11 15:00:57September 11, 2021 | Scunthorpe United vs Exeter City | 15:00:573:00 pm | League 2 | Glanford Park, Scunthorpe |
| 2021-09-18 15:00:32September 18, 2021 | Exeter City vs Sutton United | 15:00:323:00 pm | League 2 | St James Park, Exeter |
| 2021-09-25 15:00:45September 25, 2021 | Hartlepool United vs Exeter City | 15:00:453:00 pm | League 2 | Victoria Park, Hartlepool |
| 2021-10-02 15:00:47October 2, 2021 | Exeter City vs Walsall | 15:00:473:00 pm | League 2 | St James Park, Exeter |
| 2021-10-05 19:30:29October 5, 2021 | Cheltenham Town vs Exeter City | 19:30:297:30 pm | EFL Trophy | Whaddon Road, Cheltenham |
| 2021-10-09 15:00:34October 9, 2021 | Stevenage FC vs Exeter City | 15:00:343:00 pm | League 2 | Broadhall Way, Stevenage |
| 2021-10-16 15:00:35October 16, 2021 | Exeter City vs Newport County | 15:00:353:00 pm | League 2 | St James Park, Exeter |
| 2021-10-19 19:45:35October 19, 2021 | Crawley Town vs Exeter City | 19:45:357:45 pm | League 2 | Broadfield Stadium, Crawley |
| 2021-10-23 15:00:46October 23, 2021 | Exeter City vs Mansfield Town | 15:00:463:00 pm | League 2 | St James Park, Exeter |
| 2021-10-30 15:00:37October 30, 2021 | Salford City vs Exeter City | 15:00:373:00 pm | League 2 | Moor Lane, Salford |
| 2021-11-06 15:00:43November 6, 2021 | Bradford City vs Exeter City | 15:00:433:00 pm | FA Cup | Valley Parade, Bradford |
| 2021-11-09 19:00:55November 9, 2021 | Exeter City vs Bristol Rovers | 19:00:557:00 pm | EFL Trophy | St James Park, Exeter |
| 2021-11-09 19:00:59November 9, 2021 | Exeter City vs Bristol Rovers | 19:00:597:00 pm | EFL Trophy | St James Park, Exeter |
| 2021-11-13 15:00:43November 13, 2021 | Exeter City vs Oldham Athletic | 15:00:433:00 pm | League 2 | St James Park, Exeter |
| 2021-11-20 15:00:27November 20, 2021 | Exeter City vs Carlisle United | 15:00:273:00 pm | League 2 | St James Park, Exeter |
| 2021-11-23 19:45:14November 23, 2021 | Colchester United vs Exeter City | 19:45:147:45 pm | League 2 | Colchester Community Stadium |
| 2021-11-27 15:00:01November 27, 2021 | Rochdale vs Exeter City | 15:00:013:00 pm | League 2 | Spotland, Rochdale |
| 2021-12-07 19:45:50December 7, 2021 | Exeter City vs Northampton Town | 19:45:507:45 pm | League 2 | St James Park, Exeter |
| 2021-12-11 15:00:28December 11, 2021 | Exeter City vs Tranmere Rovers | 15:00:283:00 pm | League 2 | St James Park, Exeter |
| 2021-12-18 15:00:43December 18, 2021 | Port Vale vs Exeter City | 15:00:433:00 pm | League 2 | Vale Park, Port Vale |
| 2021-12-26 15:00:41December 26, 2021 | Exeter City vs Swindon Town | 15:00:413:00 pm | League 2 | St James Park, Exeter |
| 2021-12-29 15:00:42December 29, 2021 | Forest Green Rovers vs Exeter City | 15:00:423:00 pm | League 2 | New Lawn The, Nailsworth |
| 2022-01-01 15:00:08January 1, 2022 | Sutton United vs Exeter City | 15:00:083:00 pm | League 2 | Gander Green Lane |
| 2022-01-08 15:00:03January 8, 2022 | Exeter City vs Harrogate Town | 15:00:033:00 pm | League 2 | St James Park, Exeter |
| 2022-01-15 15:00:38January 15, 2022 | Exeter City vs Scunthorpe United | 15:00:383:00 pm | League 2 | St James Park, Exeter |
| 2022-01-22 15:00:33January 22, 2022 | Walsall vs Exeter City | 15:00:333:00 pm | League 2 | Bescot, Walsall |
| 2022-01-29 15:00:22January 29, 2022 | Exeter City vs Hartlepool United | 15:00:223:00 pm | League 2 | St James Park, Exeter |
| 2022-02-05 15:00:33February 5, 2022 | Swindon Town vs Exeter City | 15:00:333:00 pm | League 2 | County Ground, Swindon |
| 2022-02-08 15:00:33February 8, 2022 | Exeter City vs Leyton Orient | 15:00:333:00 pm | League 2 | St James Park, Exeter |
| 2022-02-12 15:00:26February 12, 2022 | Bradford City vs Exeter City | 15:00:263:00 pm | League 2 | Valley Parade, Bradford |
| 2022-02-19 15:00:19February 19, 2022 | Exeter City vs Barrow AFC | 15:00:193:00 pm | League 2 | St James Park, Exeter |
| 2022-02-26 15:00:09February 26, 2022 | Bristol Rovers vs Exeter City | 15:00:093:00 pm | League 2 | Memorial Ground, Bristol |
| 2022-03-05 15:00:31March 5, 2022 | Mansfield Town vs Exeter City | 15:00:313:00 pm | League 2 | Field Mill, Mansfield |
| 2022-03-12 15:00:40March 12, 2022 | Exeter City vs Salford City | 15:00:403:00 pm | League 2 | St James Park, Exeter |
| 2022-03-15 19:45:40March 15, 2022 | Exeter City vs Crawley Town | 19:45:407:45 pm | League 2 | St James Park, Exeter |
| 2022-03-19 15:00:44March 19, 2022 | Oldham Athletic vs Exeter City | 15:00:443:00 pm | League 2 | Boundary Park, Oldham |
| 2022-03-26 15:00:47March 26, 2022 | Exeter City vs Stevenage FC | 15:00:473:00 pm | League 2 | St James Park, Exeter |
| 2022-04-02 15:00:27April 2, 2022 | Newport County vs Exeter City | 15:00:273:00 pm | League 2 | Rodney Parade, Newport |
| 2022-04-09 15:00:49April 9, 2022 | Carlisle United vs Exeter City | 15:00:493:00 pm | League 2 | Brunton Park, Carlisle |
| 2022-04-15 13:00:48April 15, 2022 | Exeter City vs Colchester United | 13:00:481:00 pm | League 2 | St James Park, Exeter |
| 2022-04-18 15:00:46April 18, 2022 | Tranmere Rovers vs Exeter City | 15:00:463:00 pm | League 2 | Prenton Park, Tranmere |
| 2022-04-23 15:00:44April 23, 2022 | Exeter City vs Rochdale | 15:00:443:00 pm | League 2 | St James Park, Exeter |
| 2022-04-30 15:00:47April 30, 2022 | Northampton Town vs Exeter City | 15:00:473:00 pm | League 2 | County Ground, Northampton |
| 2022-05-07 15:00:43May 7, 2022 | Exeter City vs Port Vale | 15:00:433:00 pm | League 2 | St James Park, Exeter |
